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Wednesday, July 29, 2020 | History

2 edition of new ex-vivo model of endothelial damage/dysfunction found in the catalog.

new ex-vivo model of endothelial damage/dysfunction

Eman A. Y. Al-Yemeni

new ex-vivo model of endothelial damage/dysfunction

application to hypertension in pregnancy

by Eman A. Y. Al-Yemeni

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  • 3 Currently reading

Published by University of Birmingham in Birmingham .
Written in English


Edition Notes

Thesis (M.Phil) - University of Birmingham, School of Medicine, Haemostasis, Thrombosis and Vascular Biology Unit, 2003.

Statementby Eman A.Y. Al-Yemeni.
The Physical Object
Paginationxii, 89 p. ;
Number of Pages89
ID Numbers
Open LibraryOL21688563M

High Systolic Blood Pressure Induces Cerebral Microvascular Endothelial Dysfunction, Neurovascular Unit Damage, and Cognitive Decline in Mice. Olivia de Montgolfier, Anthony Pinçon, Philippe Pouliot, Marc-Antoine Gillis, Jonathan Bishop, John G. Sled, Louis Villeneuve, Guylaine Ferland, Bernard I. Lévy, Frédéric Lesage, Nathalie Thorin. Title: Endothelial Dysfunction: Methods of Assessment and Application to Hypertension VOLUME: 10 ISSUE: 29 Author(s):Sunil Nadar, Andrew D. Blann and Gregory Y.H. Lip Affiliation:Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital,Birmingham B18 7QH, England, UK. Keywords:endothelial dysfunction, endothelial damage, endothelial .

What is endothelial injury and dysfunction present and discuss with your group the following: 1. What is endothelial injury and dysfunction? 2. How does a?dysfunctional endothelium? differfrom a?functional? one? 3. What is your clinical/investigative population of interest, and how does endothelial/vascular injury and/or dysfunction relate to your clinical/investigative . The results of the present ex vivo study yield that the most suitable starting dose to develop a repeatable and reproducible in vivo model of endothelial disease in rabbits is mL of % BAC. The toxic action of BAC would counteract the proliferative capacity of rabbit CECs, hence making this species more suitable for such a model.

For references and more information, see the section on Endothelial Dysfunction in the Vitamin C article. [Download PDF] Coenzyme Q 10 What it does. General. Coenzyme Q 10 is a compound that can be made inside the body and obtained from food and dietary supplements.; Coenzyme Q 10 helps the body convert food into useable energy and functions as an . Biomedicines, an international, peer-reviewed Open Access journal. Dear Colleagues, The Special Issue, “Endothelial Dysfunction: From Pathophysiology to Novel Therapeutic Approaches”, will focus on the pathophysiology of endothelial dysfunction, new biomarkers for endothelial dysfunction related to cardiovascular disorders or tumors, and novel therapeutic approaches for endothelial.


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New ex-vivo model of endothelial damage/dysfunction by Eman A. Y. Al-Yemeni Download PDF EPUB FB2

Figure 1. Pathways from endothelial dysfunction to hypertension. ROS indicates reactive oxygen species. Interestingly, despite the low basal vascular tone of the lung under physiological conditions, sympathetic control of vessel tone becomes important during the development of pulmonary artery hypertension (PAH): In the monocrotaline rat model of PAH, sympathetic Cited by:   The endothelium enables communication between blood and tissues and is actively involved in cardiovascular homeostasis.

Endothelial dysfunction has been recognized as an early step in the development of cardiovascular diseases: respectively, endothelium represents a potential therapeutic niche with multiple targets. The purpose of the book is to point out some recent findings of endothelial Author: Helena Lenasi.

This new and reproducible ex vivo model of corneal endothelial cell injury using phacoemulsification (US) reduces the need for more expensive and cumbersome in vivo models. • The new treatment method uses secreted factors from mesenchymal stem cells to treat and prevent corneal endothelial cell by: 3.

Using this in vivo approach, visfatin/eNampt was again proved as an inductor of endothelial dysfunction. As for ex vivo or in vitro studies, the Nampt activity and the activation of TLR4 receptors Cited by: 2. In the last decade, an additional method to study ex vivo patient's endothelial cells has become available.

InFeng et al. 87 first described a method to sample endothelial cells using an endovascular approach. They aimed at harvesting viable vascular endothelial cells in order to analyse gene expression at the sites of vascular damage.

The corrosion of biodegradable Fe-based implants releases hydroxyl radicals (HO). HO have a deleterious impact on endothelial function in an ex-vivo rat aorta model. HO cause oxidative stress and reduce nitric oxide availability in rat aortic rings.

This new ex-vivo model may act as a point of reference for similar studies. Preliminary studies have confirmed the ability of eFGF-1 to accelerate corneal endothelial regeneration in the cryogenic injury model in the rabbit (See Figure 1, p.

78). Further research is ongoing to better quantitate the efficacy of eFGF-1 and to determine proper dosing levels (internal data, Trefoil Inc.). • Adverse events.

Finally, ex vivo-expanded rabbit CEC were transplanted into a model of endothelial damage in rabbit corneas. Results: Treatment of rabbit and nonhuman primate CEC in vitro with IGF-1, heregulin beta, and activin A induced an upregulation of PI3K/Akt and Smad2 signaling pathways and an increase in proliferation and migration of CEC expressing ZO.

Patel SV, et al. Human corneal endothelial cell transplantation in a human ex vivo model. Invest Ophthalmol Vis Sci. ;50(5)– PubMed PubMedCentral CrossRef Google Scholar. Objective To investigate the beneficial role of prebiotics on endothelial dysfunction, an early key marker of cardiovascular diseases, in an original mouse model linking steatosis and endothelial dysfunction.

Design We examined the contribution of the gut microbiota to vascular dysfunction observed in apolipoprotein E knockout (Apoe−/−) mice fed an n-3 polyunsaturated fatty acid.

Endothelial dysfunction refers to several pathological conditions, including altered anticoagulation and anti‐inflammatory activities, impaired modulation of vascular growth, and dysregulation of vascular remodeling (Mombouli and Vanhoutte, ).

However, the term endothelial dysfunction is most commonly used to refer to decreases in. Background. Damage to the endothelium has been established as a key pathological process in lung transplantation and ex vivo lung perfusion (EVLP), a new technology that provides a platform for the assessment of injured donor lungs.

Damage to the lung endothelial glycocalyx, a structure that lines the endothelium and is integral to vascular barrier function, has been.

However, the limited availability of human endothelial tissue represents a major restriction. Other methods for an ex vivo evaluation of endothelial dysfunction include the quantification of circulating ECs (Boos et al., ), endothelial microparticles, (Horstman et al., ) or circulating endothelial progenitor cells (Chen et al., ).

Selected Endothelial Responses after Ionizing Radiation Exposure, Endothelial Dysfunction - Old Concepts and New Challenges, Helena Lenasi, IntechOpen, DOI: /intechopen Available from: Bjorn Baselet, Raghda Ramadan, Abderrafi Mohammed Benotmane, Pierre Sonveaux, Sarah Baatout and An Aerts (December 20th ).

Weber, C., Jenke, A., Chobanova, V. et al. Targeting of cell-free DNA by DNase I diminishes endothelial dysfunction and inflammation in a rat model of cardiopulmonary bypass. Sci Rep 9, Endothelial dysfunction is an initial pathophysiological mechanism of vascular damage and is further recognized as an independent predictor of negative prognosis in diabetes-induced micro- and macrovascular complications.

Insight into the capability of zebrafish to model metabolic disease like obesity and type II diabetes has increased and new. Endothelial dysfunction is a hallmark of tissue injury and is believed to initiate the development of vascular diseases.

Sphingosine-1 phosphate receptor-1 (S1P 1. The relationship between smoking and endothelial dysfunction is also discussed. The connection between different pulmonary rehabilitation programs, arterial stiffness and pulse wave velocity (PWV) is presented. Endothelial dysfunction is a significant prognostic factor of COPD, which can be characterized by PWV.

In vascular diseases, endothelial dysfunction is a systemic pathological state of the with acting as a semi-permeable membrane, the endothelium is responsible for maintaining vascular tone and regulating oxidative stress by releasing mediators, such as nitric oxide, prostacyclin and endothelin, and controlling local angiotensin-II activity.

Endothelial dysfunction – A predictor of atherosclerosis Dr. Namrata Chhabra MD Additional Professor, Department of Biochemistry, S. Medical College, Mauritius (Received 01 September and accepted 12 July ) ABSTRACT: Endothelial dysfunction is a systemic disorder and a.

The goal of the current study was to investigate the effect of aging on the development of endothelial dysfunction in a murine model of sepsis, and to compare it with the effect of genetic deficiency of the endothelial isoform of nitric oxide synthase (eNOS).

Cecal ligation and puncture (CLP) was used to induce sepsis in mice. Survival rates were monitored .EPCs. EPCs were discovered in as circulating cells with the ability to differentiate into mature endothelium and take part in neoangiogenesis ().EPCs share markers of hematopoietic (CD34 and CD) and endothelial (KDR, CD31, and vWf) lineages (), are derived from bone marrow, and can be mobilized to the peripheral circulation in response to many stimuli ().Vascular endothelial cells normally perform several key homeostatic functions such as keeping blood fluid, regulating blood flow, regulating macromolecule and fluid exchange with the tissues, preventing leukocyte activation, and aiding in immune surveillance for pathogens.

Injury or cell death impairs or prevents conduct of these activities, resulting in dysfunction. Most endothelial .